Pivikto - Alpelisib film coated tablets 150 mg

Information About Alpelisib

What is Alpelisib?

Alpelisib is a targeted therapy used in the treatment of certain types of breast cancer. It is specifically prescribed for patients with HR-positive, HER2-negative advanced or metastatic breast cancer that has a PIK3CA mutation.

How Does Alpelisib Work?

Alpelisib works by targeting and inhibiting the PI3K pathway, which is involved in the growth and survival of cancer cells. By blocking this pathway, Alpelisib helps prevent cancer cells from multiplying and spreading, thereby slowing the progression of the disease.

Common Side Effects of Alpelisib

While Alpelisib can be effective in treating breast cancer, it can also cause a range of side effects. Commonly reported side effects include:

• Increased blood glucose levels

• Diarrhea

• Rash

• Nausea

• Vomiting

• Fatigue

• Increased creatinine levels in the blood

• Lymphocytopenia (low levels of lymphocytes)

• Increased gamma-glutamyltransferase

• Increased alanine aminotransferase levels

• Decreased hemoglobin

• Increased blood lipase levels

• Decreased appetite

• Stomatitis (inflammation of the mouth)

• Weight loss

• Hypoglycemia (low blood glucose levels)

• Decreased calcium levels in the blood

• Prolonged activated partial thromboplastin time (aPTT)

• Hair loss

Important Considerations

If you are being treated with Alpelisib or considering this medication, consult with your healthcare provider to discuss the potential benefits and risks. Regular monitoring of blood glucose levels and other lab tests may be necessary during treatment to manage and mitigate side effects. Always follow your healthcare provider’s instructions and report any unusual symptoms.

Conclusion

Alpelisib represents a significant advancement in the treatment of HR-positive, HER2-negative breast cancer with a PIK3CA mutation. While it offers promising results, being aware of and managing possible side effects is essential for maintaining quality of life during treatment.

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