Olanib (Olaparib) 150 mg

Indications:

It is prescribed as monotherapy for treating adults with deleterious or suspected deleterious germline BRCA-mutated (gBRCAm), HER2-negative metastatic breast cancer with germline BRCA mutations. Prior to receiving chemotherapy, these patients must have undergone some form of treatment. Furthermore, it should be noted that patients with hormone receptor-positive breast cancer should either have progressed on or should be deemed ineligible to receive endocrine therapy. Until the germline BRCA mutation has been confirmed, the treatment with Olanib cannot be initiated.

In the case of high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancers, olanib can also be used as a maintenance monotherapy in adults with platinum-sensitive relapsed (PSR) disease. It is important that platinum-based chemotherapy is shown to be effective in patients, either completely or partially.

The dosage and administration of this medication are as follows:

It is important to note that Olaparib capsules (50 mg) should not be substituted for Olaparib tablets (100 mg and 150 mg) on the basis of milligram-to-milligram basis due to the differences in dosing and bioavailability between the two.

It is recommended that you take 400 mg three times a day (eight capsules of 50 mg each), giving you a total of 800 mg per day. As long as the disease does not progress or the toxicity is unacceptable, the treatment should be continued. In the event that a dose is missed, continue to take the next dose at its scheduled time as soon as possible. It is important to swallow capsules whole, without chewing, dissolving, or opening them before taking them. You should avoid taking capsules that have been deformed or that are leaking.

For the management of adverse reactions, it is recommended to consider treatment interruption or dose reduction as a means of managing the reaction. There is a recommendation to reduce the dosage to 200 mg (four capsules containing 50 mg) twice daily. Reduce dosage to 100 mg (two 50 mg capsules twice daily) if further reduction is needed.

If you are using CYP3A inhibitors concurrently with a strong CYP3A inhibitor, it is recommended that you modify the dose in some way. In the event that it is unavoidable, you should reduce your Olaparib dosage to 150 mg twice a day (for strong inhibitors) or 200 mg twice a day (for moderate inhibitors).

Modifications to Dosage for Patients with Renal Impairment: In the case of mild renal impairment, no dose adjustment is necessary. The recommended dosage of this medicine is 300 mg twice a day (six capsules of 50 mg) if you have moderate renal impairment. No studies have been conducted to evaluate the effects of this medication in patients with severe renal impairment or end-stage renal disease.

It has not yet been determined as to whether Olaparib is safe and effective for use in pediatric patients.

It is very important to follow the prescription guidelines provided by a registered physician when taking any medication.

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